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Category: Surface Modification

Click Chemistry and Diazo Transfer Method

By BroadPharm
|
June 24, 2020
| No Comments
| Biotin Labeling, Drug Development / Delivery, Dye Labeling, Oligonucleotides, PEG and Click Chemistry, PEG in Antibody Drug Conjugates (ADC), PEG Linker Chemistry, Product, Surface Modification, Uncategorized

Click Chemistry, coined by K. Barry Sharpless of Scripps Research, has been widely used in in developing new drug molecules and non-pharamceuticals. Chemists developed a new method called the “diazotransfer” reaction where they use fluorosulfuryl azide to convert primary amines into azides in a more quick, efficient and safe way under room-temperature conditions. It also […]

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Posted in Biotin Labeling, Drug Development / Delivery, Dye Labeling, Oligonucleotides, PEG and Click Chemistry, PEG in Antibody Drug Conjugates (ADC), PEG Linker Chemistry, Product, Surface Modification, Uncategorized

Optimizing Early Zika Virus Detection: PEG Used as Blocking Reagent for Graphene-Based Biosensor

By Sarah Beltier
|
April 9, 2019
| No Comments
| Surface Modification

In an effort to improve diagnosis, a novel platform using a graphene-based biosensor has… This technology, in works with PEG as a blocking reagent, showed limited cross-reactivity…

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Posted in Surface Modification

PEGylation Chemistry

By BroadPharm
|
September 26, 2018
| No Comments
| Biotin Labeling, Drug Development / Delivery, Dye Labeling, PEG and Click Chemistry, PEG in Antibody Drug Conjugates (ADC), PEG Linker Chemistry, Surface Modification

The introduction of a PEG linker to a molecule provides many benefits for pharmaceutical and biotech R&D due to its water solubility, lower toxicity and non-immunogenicity. The introduction of different functional groups to the end of a PEG linker allows for more site-specific reactions. For example, proteins have various amino acid residue that may be […]

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Posted in Biotin Labeling, Drug Development / Delivery, Dye Labeling, PEG and Click Chemistry, PEG in Antibody Drug Conjugates (ADC), PEG Linker Chemistry, Surface Modification

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