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Marine mussels are able to adhere to a variety of surfaces in wet conditions through the byssus, a collection of tough, silky, wet fibrous strands. Researchers at UC Berkeley and Nanjing University had a goal to make man-made adhesives by mimicking the adhesion of Lysine-DOPA in marine mussels. This can help make products such as […]
University of Penn wrote this amazing article on Click Chemistry, a new popular approach in how we can find answers to how certain pathogens, including SARS-CoV-2, affects hosts and avoids detection by the immune system. Source: https://penntoday.upenn.edu/news/new-tool-cell-biologistsOur Click Chemistry Tools: https://broadpharm.com/web/products.php?category1=Click%20ChemistryImage Source: https://doi.org/10.1101/2020.04.07.030445 #ClickChemistry #PennState #research #PEGlinkers #PEGylation #PROTAC #dyelabeling #bioconjugation #chemistry #PEGsupply #PEGreagent #drugdiscovery […]
A team at University of Southern California has engineered a faster way to effectively target malignant cells without damaging healthy tissue, which can help improve treatments for many different types of cancer. Current ADCs (antibody-drug conjugates) are made using a process with limited stability and efficacy. Homogeneous ADCs have a higher potential for clinical effectiveness, […]
Excess copper from Alzheimer’s disease can be removed using a synthesized drug that also photo-oxygenates amyloid-β plaques. Click Chemistry has been a potential option for this process. “Copper in amyloid-β–copper aggregates can catalyse an azide–alkyne cycloaddition – the classic click reaction – to turn the contents of the silica nanoparticles into a therapeutic compound.” Source: […]
Click Chemistry, coined by K. Barry Sharpless of Scripps Research, has been widely used in in developing new drug molecules and non-pharamceuticals. Chemists developed a new method called the “diazotransfer” reaction where they use fluorosulfuryl azide to convert primary amines into azides in a more quick, efficient and safe way under room-temperature conditions. It also […]
Researchers at University of Washington created a zwitterionic polymer that is able to trade-off between nonspecific interactions using BroadPharm’s PEGs. Covalent binding of hydrophilic polymers such as PEGs and zwitterionic polymers can prevent the immune system from recognizing its shielded protein. Zwitterions maintain an overall neutral charge, which gives them a high hydration capacity. Particles […]
In this research from Cornell, mAbs bioconjugates are observed by the targeted delivery of small molecules, proteins, nucleic acids and more through expressions. By continuing to improve the consistency of conjugation, ADCs can increase its efficacy towards the targeted cells and tolerability. They have found two of their expression platforms to be able to generate […]
2019 was a very exciting year with three ADC drugs approved by FDA, followed by one more new ADC, Sacituzumab Govitecan (IMMU-132) approved in 2020 from Immunomedics. IMMU-132, also known as Trodelvy, is an immune targeted therapy medicine for triple-negative breast cancer. The drug consists of sacituzumab and SN-38 with a linker in between. Sacituzumab […]
PEG Linkers can be used to see if liposomes that carry antigen can be decorated with different diether lipids. Source: https://lnkd.in/gCgp6q8! Azide-PEG8-Alcohol: https://lnkd.in/ggEqehh #research #PEGlinkers #PEGylation #PEGvendor #PROTAC #dyelabeling #bioconjugation #chemistry #PEGsupply #PEGreagent #drugdiscovery #drugdelivery #amino #assay #lipids #antigen
New #FDA approved ADC drug this month! Exciting news. Article: https://lnkd.in/eWKXgKu We are contributing in making new ADC linkers to empower this field of research. You can check out our ADC Linkers here: https://bit.ly/2z9oQcb #research #PEGlinkers #PEGylation #PEGvendor #PROTAC #dyelabeling #bioconjugation #chemistry #PEGsupply #PEGreagent #drugdiscovery #drugdelivery #ADCs #breastcancer #breastcancerawareness #PEG #ADClinker
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