Click Chemistry Becoming A New Popular Approach

By BroadPharm

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July 22, 2020

| Biotin Labeling, Drug Development / Delivery, Dye Labeling, PEG and Click Chemistry, PEG in Antibody Drug Conjugates (ADC), PEG Linker Chemistry, Product

University of Penn wrote this amazing article on Click Chemistry, a new popular approach in how we can find answers to how certain pathogens, including SARS-CoV-2, affects hosts and avoids detection by the immune system. Source: https://penntoday.upenn.edu/news/new-tool-cell-biologistsOur Click Chemistry Tools: https://broadpharm.com/web/products.php?category1=Click%20ChemistryImage Source: https://doi.org/10.1101/2020.04.07.030445 #ClickChemistry #PennState #research #PEGlinkers #PEGylation #PROTAC #dyelabeling #bioconjugation #chemistry #PEGsupply #PEGreagent #drugdiscovery […]

A New Method for ADCs!

By BroadPharm

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July 15, 2020

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| Biotin Labeling, Drug Development / Delivery, Dye Labeling, PEG and Click Chemistry, PEG in Antibody Drug Conjugates (ADC)

A team at University of Southern California has engineered a faster way to effectively target malignant cells without damaging healthy tissue, which can help improve treatments for many different types of cancer. Current ADCs (antibody-drug conjugates) are made using a process with limited stability and efficacy. Homogeneous ADCs have a higher potential for clinical effectiveness, […]

Click Chemistry and Diazo Transfer Method

By BroadPharm

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June 24, 2020

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| Biotin Labeling, Drug Development / Delivery, Dye Labeling, Oligonucleotides, PEG and Click Chemistry, PEG in Antibody Drug Conjugates (ADC), PEG Linker Chemistry, Product, Surface Modification, Uncategorized

Click Chemistry, coined by K. Barry Sharpless of Scripps Research, has been widely used in in developing new drug molecules and non-pharamceuticals. Chemists developed a new method called the “diazotransfer” reaction where they use fluorosulfuryl azide to convert primary amines into azides in a more quick, efficient and safe way under room-temperature conditions. It also […]

PEGs and Zwitterions

By BroadPharm

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June 10, 2020

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| Biotin Labeling, Drug Development / Delivery, Dye Labeling, Oligonucleotides, PEG and Click Chemistry, PEG in Antibody Drug Conjugates (ADC), PEG Linker Chemistry

Researchers at University of Washington created a zwitterionic polymer that is able to trade-off between nonspecific interactions using BroadPharm’s PEGs. Covalent binding of hydrophilic polymers such as PEGs and zwitterionic polymers can prevent the immune system from recognizing its shielded protein. Zwitterions maintain an overall neutral charge, which gives them a high hydration capacity. Particles […]

Cornell’s Research on ADCs

By BroadPharm

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June 3, 2020

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| Biotin Labeling, Drug Development / Delivery, Dye Labeling, Oligonucleotides, PEG and Click Chemistry, PEG in Antibody Drug Conjugates (ADC), PEG Linker Chemistry

In this research from Cornell, mAbs bioconjugates are observed by the targeted delivery of small molecules, proteins, nucleic acids and more through expressions. By continuing to improve the consistency of conjugation, ADCs can increase its efficacy towards the targeted cells and tolerability. They have found two of their expression platforms to be able to generate […]

Some Findings About IMMU-132!

By BroadPharm

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May 28, 2020

| 1 Comment

| Biotin Labeling, Drug Development / Delivery, Oligonucleotides, PEG and Click Chemistry, PEG in Antibody Drug Conjugates (ADC), PEG Linker Chemistry, Product

2019 was a very exciting year with three ADC drugs approved by FDA, followed by one more new ADC, Sacituzumab Govitecan (IMMU-132) approved in 2020 from Immunomedics. IMMU-132, also known as Trodelvy, is an immune targeted therapy medicine for triple-negative breast cancer. The drug consists of sacituzumab and SN-38 with a linker in between. Sacituzumab […]

PEG Linkers in Determining the Binding Relationship with Liposomes

By BroadPharm

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May 6, 2020

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| Biotin Labeling, Drug Development / Delivery, PEG and Click Chemistry, PEG in Antibody Drug Conjugates (ADC), PEG Linker Chemistry

PEG Linkers can be used to see if liposomes that carry antigen can be decorated with different diether lipids. Source: https://lnkd.in/gCgp6q8! Azide-PEG8-Alcohol: https://lnkd.in/ggEqehh #research #PEGlinkers #PEGylation #PEGvendor #PROTAC #dyelabeling #bioconjugation #chemistry #PEGsupply #PEGreagent #drugdiscovery #drugdelivery #amino #assay #lipids #antigen

An Example of PEG Linker Used in Nanotechnology

By BroadPharm

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April 15, 2020

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| Biotin Labeling, Drug Development / Delivery, Dye Labeling, PEG and Click Chemistry, PEG Linker Chemistry

Nanomedical Diagnostics studied signal-to-noise ratio (SNR) in graphene biosensors to show that graphene-based platforms should be popularized for next generation diagnostics due to Field Effect Biosensing (FEB) based biosensors. A PEG linker was used in their solution for kinetic analysis. They created a portable, low-cost platform that has advantages in response time, fabrication ease, sensitivity […]

Single-Cell Encapsulation via Click Chemistry Involving DBCO-PEG

By BroadPharm

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March 11, 2020

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| Biotin Labeling, Drug Development / Delivery, Dye Labeling, PEG and Click Chemistry, PEG in Antibody Drug Conjugates (ADC), PEG Linker Chemistry

Recently published by the School of Medicine of Stanford University, researchers have been looking into new ways to improve stem cell therapy by decreasing the time, risk and cost. During the process, they have created an experimental design involving click-chemistry and glycoengineering to test different kinds of stiffness of the polymer coating in order to […]

PEGylation Chemistry

By BroadPharm

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September 26, 2018

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| Biotin Labeling, Drug Development / Delivery, Dye Labeling, PEG and Click Chemistry, PEG in Antibody Drug Conjugates (ADC), PEG Linker Chemistry, Surface Modification

The introduction of a PEG linker to a molecule provides many benefits for pharmaceutical and biotech R&D due to its water solubility, lower toxicity and non-immunogenicity. The introduction of different functional groups to the end of a PEG linker allows for more site-specific reactions. For example, proteins have various amino acid residue that may be […]

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Category: Biotin Labeling