Click Chemistry and Diazo Transfer Method

Click Chemistry, coined by K. Barry Sharpless of Scripps Research, has been widely used in in developing new drug molecules and non-pharamceuticals. Chemists developed a new method called the “diazotransfer” reaction where they use fluorosulfuryl azide to convert primary amines into azides in a more quick, efficient and safe way under room-temperature conditions. It also allows newly generated azides to used instantly without any further processing. The chemists at Scripps also used the technique to make triazole variants of a new anti-tuberculosis drug that contains 100 times increased potency and more efficient drug properties compared to the original molecule. Source:

Here at BroadPharm, we provide a variety of Click Chemistry tools. You can check them out here at You can also contact us for inquiries on custom synthesis projects. We would love to contribute to your research and discovery.


#clickchemistry #ScrippsResearch #PEGlinkers #PEGylation #PROTAC #dyelabeling #bioconjugation #chemistry #PEGsupply #PEGreagent #drugdiscovery #drugdelivery